Regular coffee ingestion continues to be strongly associated with a variety of benefits. There’s also little doubt in my mind there’s additional benefits and synergism by including AlphaJoe to the daily coffee intake. A review paper just out, “Impact of coffee intake on human aging: Epidemiology and cellular mechanisms” covers the topic in depth. Bottom line is, if you’re not drinking coffee, you’re doing it wrong! For those who don’t want to read the paper, some of the key findings:
- The regular consumption of moderate doses of coffee attenuates all-cause mortality
- Coffee intake attenuates age-associated diseases (cardiovascular, stroke, cancer)
- Coffee and its main components (caffeine, chlorogenic acids) control stress adaptation
- Coffee intake preserves the main biological mechanisms of aging
“Moderate doses” are defined as 2-3 cups daily.
Impact of coffee intake on human aging: Epidemiology and cellular mechanisms
Ageing Research Reviews, Volume 102, December 2024, Review article
Abstract
The conception of coffee consumption has undergone a profound modification, evolving from a noxious habit into a safe lifestyle actually preserving human health. The last 20 years also provided strikingly consistent epidemiological evidence showing that the regular consumption of moderate doses of coffee attenuates all-cause mortality, an effect observed in over 50 studies in different geographic regions and different ethnicities.
Coffee intake attenuates the major causes of mortality, dampening cardiovascular-, cerebrovascular-, cancer- and respiratory diseases-associated mortality, as well as some of the major causes of functional deterioration in the elderly such as loss of memory, depression and frailty. The amplitude of the benefit seems discrete (17 % reduction) but nonetheless corresponds to an average increase in healthspan of 1.8 years of lifetime. This review explores evidence from studies in humans and human tissues supporting an ability of coffee and of its main components (caffeine and chlorogenic acids) to preserve the main biological mechanisms responsible for the aging process, namely genomic instability, macromolecular damage, metabolic and proteostatic impairments with particularly robust effects on the control of stress adaptation and inflammation and unclear effects on stem cells and regeneration.
Further studies are required to detail these mechanistic benefits in aged individuals, which may offer new insights into understanding of the biology of aging and the development of new senostatic strategies. Additionally, the safety of this lifestyle factor in the elderly prompts a renewed attention to recommending the maintenance of coffee consumption throughout life as a healthy lifestyle and to further exploring who gets the greater benefit with what schedules of which particular types and doses of coffee.
Full paper HERE.
Will Brink is the owner of the Brinkzone Blog. Will has over 30 years experience as a respected author, columnist and consultant, to the supplement, fitness, bodybuilding, and weight loss industry and has been extensively published. Will graduated from Harvard University with a concentration in the natural sciences, and is a consultant to major supplement, dairy, and pharmaceutical companies.
His often ground breaking articles can be found in publications such as Lets Live, Muscle Media 2000, MuscleMag International, The Life Extension Magazine, Muscle n Fitness, Inside Karate, Exercise For Men Only, Body International, Power, Oxygen, Penthouse, Women’s World and The Townsend Letter For Doctors.
He’s also been published in peer reviewed journals.
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