Creatine continues to demonstrate a wide range of potential benefits, but a recent study suggests it may have some value in weight loss. Scientists found that when they impaired creatine transportation into cells of mice, it blunted the metabolic effects the mice would normally have to a high fat diet (via thermogenesis), and when they fed the mice creatine, it restored it. When they gave the mice creatine, it actually prevented diet induced obesity and increased whole-body energy expenditure, leading the researchers to hypothesize that “…enhancing creatine uptake into adipocytes may offer an opportunity to combat obesity and obesity-associated metabolic dysfunction.” Do some people have impaired creatine uptake into cells leading to a reduced whole-body energy expenditure in response to food ingestion? That could be a missing link for some people that seem to gain weight easier than others? It’s unclear at this time due to lack of research, but it’s a very interesting and potentially valuable area of inquiry. It’s interesting to note also they found that in human fat cells, cell-surface creatine transporter (CrT) was was correlated with a lower body mass index and increased insulin sensitivity. So does increasing creatine tissue levels improve insulin sensitivity and improve metabolic responses to calories ingested in healthy humans? That has yet to be studied directly yet, but various lines of evidence suggests the answer is yes. How much of an impact it would actually have is also unclear.
What can readers take away from this now? Considering the wide range of potential benefits of creatine for both body and mind (hence why it’s found in Bomb Proof Coffee!), this may be another good reason to keep tissue creatine levels topped off. It does stand to reason that sub par tissue creatine levels might inhibit optimal metabolic function in humans, but we need more data on that one.
Until there’s solid human data examining this one, it’s just a guess, but I have been a professional guesser for decades now, and more often than not, my hunches have been correct. OK, I didn’t think Amazon would go onto be the monster sized company it is today, and should have grabbed some stock back in the day, but no one is perfect!
Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity
Depleting creatine levels in thermogenic adipocytes by inhibiting creatine biosynthesis reduces thermogenesis and causes obesity. However, whether creatine import from the circulation affects adipocyte thermogenesis is unknown.
Here we show that deletion of the cell-surface creatine transporter (CrT) selectively in fat (AdCrTKO) substantially reduces adipocyte cre-atine and phosphocreatine levels, and reduces whole-body energy expenditure in mice. AdCrTKO mice are cold intolerant and become more obese than wild-type animals when fed a high-fat diet. Loss of adipocyte creatine transport blunts diet- and β3-adrenergic-induced thermogenesis,
whereas creatine supplementation during high-fat feeding increases whole-body energy expenditure in response to β3-adrenergic agonism. In humans, CRT expression in purified subcutaneous adipocytes correlates with lower body mass index and increased insulin sensitivity.
Our data indicate that adipocyte creatine abundance depends on creatine sequestration from the circulation. Given that it affects whole-body energy expenditure, enhancing creatine uptake into adipocytes may offer an opportunity to combat obesity and obesity-associated metabolic dysfunction.
Full Paper HERE.
Will Brink is the owner of the Brinkzone Blog. Will has over 30 years experience as a respected author, columnist and consultant, to the supplement, fitness, bodybuilding, and weight loss industry and has been extensively published. Will graduated from Harvard University with a concentration in the natural sciences, and is a consultant to major supplement, dairy, and pharmaceutical companies.
His often ground breaking articles can be found in publications such as Lets Live, Muscle Media 2000, MuscleMag International, The Life Extension Magazine, Muscle n Fitness, Inside Karate, Exercise For Men Only, Body International, Power, Oxygen, Penthouse, Women’s World and The Townsend Letter For Doctors.
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