In this vid I give quick look at some technologies that greatly enhance solubility of compounds known for their poor solubility. Such a technology applied to various supplements could greatly improve their bioavailability. The link in the vid also takes you to another vid and article with additional info on the topic BTW.

16 Comments
  1. Hondo 5 years ago

    Hi Will,
    very interesting video and I look forward to your follow-ups on the matter of bio-availabilty and absorption. Until then I do have a question and I understand what I just watched was in the baby stages until you explain more. However, and I am not as learned in this field as you, but here it my question. You demonstrated Chrysin, for example and how insoluble it is. Did I understand that this is placed into water? I seem to recall you said these were placed into water. I am only being very curious here, but how accurate is this? We could place a piece of cooked steak into a jar of water and it would`t break down either. Isn’t there a change that would happen in the stomach and liver that would be different from placing these in a jar of water? Again, I know you will be providing further information, but my overly curious mind is running on max.
    Have a nice weekend and thanks for all the great videos!
    Best,
    ~ Hondo

    • Author
      Will Brink 5 years ago

      Compounds are either water soluble or lipid (fat ) soluble. Solubility in either is essential to how it’s absorbed and by what route, etc. As everything in the human body takes place in a water medium, that’s standard information as to how a compound will behave and seeing how they dissolve in water is a standard test. My vid is of course very simplified to the issue, but meant to give people and idea of it vs. something that would hold up to scientific scrutiny per se.
      Vid & article linked in this vid goes into depth on that if interested in additional details on the importance of solubility on absorption you may find adds useful information to your Q. Isolated compounds will react much differently than say a whole food like a steak, which contains all manner of compounds that are water soluble, fat soluble, and insoluble in either, and there’s no real comparison that can be made there.

      • Hondo 5 years ago

        Thanks for your reply and now I understand. I never had a Chemistry class, not even in university. But what you are saying makes sence. I am anticipating the follow up videos. Thanks again Will!

  2. Michael 5 years ago

    Hey Will,
    Exciting improvements. Thanks for the video. I did have a question about chrysin. I notice a lot of compounding pharmacies make a cream to apply to the skin. Is it’s bio availability increased by this method or still worthless?
    Thanks

    • Author
      Will Brink 5 years ago

      I don’t know of any studies that looked at the topical route for chrysin.

      • Michael 5 years ago

        Thanks for the reply Will, I have never had any luck finding studies either. Make me wonder why some places talk about it like its effectiveness is known fact.

  3. Cisco 5 years ago

    Good stuff – was looking through your website for collagen protein or hydrolyzed collagen protein but couldn’t find anything – it is suppose to be over 95% absorbed by the body compared to whey protein with around 50% absorption – whats your thought on Collagen Protein – appreciate your feedback
    cisco

    • Author
      Will Brink 5 years ago

      collagen is a very low quality protein and a poor source of protein. It may have some uses for joint pain due to the Collagen, but as a source of protein, it’s very poor quality.

      • cisco 5 years ago

        Thanks a lot – was just wondering cause i got this of a website –>Hydrolyzed Collagen Protein has the highest Net Protein Utilization, or NPU (which measures how much protein is actually utilized by the body), higher than whey, soy, pea or other popular protein forms. Hydrolyzed Collagen Protein has a 95% absorption rate, which is significantly higher than the 53% absorption rate of whey protein, the 26% of soy protein and the 16% of pea protein.
        and since 60% or what of the body is made elf collagen protein i would have never guessed its a poor source

        • MarkLloyd 5 years ago

          For all practical purposes HCP might as well be old shoes boiled down in HCL Stay away! How well something’s absorbed doesn’t help you if it’s something you don’t want to absorb!

          • Cisco 5 years ago

            Mark thanks but theres still the question that if our bodies is made from collagen and bovine collagen is the most similar why would you not want more of that ? specially since we are losing collagen from a certain age onwards ….Whey is a waste products too as fas as i know so how can a diary waste product be something you want in your body 🙂 just saying since Will mentioned collagen being cheap ….anyway when i wiki it it doesn’t sound as bad as you guys out it it seems to be filled with Essential amino acids …i guess i will need to do further research here but thanks folks

        • Author
          Will Brink 5 years ago

          We know Collagen is not even a complete protein, so how anyone would claim
          a high NPU I don’t know. It does not. Regardless, it’s been considered a true junk protein
          by scientists forever and was sold due to being cheap. It’s made form boiling
          hides left over animal parts.You’d have ask those making the claim for that supposed NPU score, which
          is and old and seldom used scoring system regardless. It’s garbage as far as being used for protein replacement.

          • MarkLloyd 5 years ago

            I never did get the “we’re made of it, so we should eat it” pitch. Would anyone eat hair to improve their own headful?…teeth for dental health? Conversely, we’re not “made of” leaves, stems, roots, fruits….thus, apparently, we shouldn’t eat any plant-based food.

          • Cisco 5 years ago

            Mark LOL now thats a weird comparison my friend…you wouldn’t eat hair to get hair hair is made of protein, most of our body is hence Protein (first) then water and fats …now it turns out a lot of ppl go away from carbs and increase the high fast that wasn’t like that years ago …you guys tell me collagen is bad in a few years it may be the bomb who knows – body is made from water too STOP drinking water for a while see how that goes 😉 anyway lets not blow this out of proportion …I would say collagen protein is alright BUT I wouldn’t replace my 200-240 hrs protein I eat a day with ONLY collagen …. i guess its the combination and have 20-30 grs a day for the sake of joints hair nails and all the other good stuff thats made of collagen doesn’t seem like a bad idea 🙂 thanks for your feedback and Will too – its great to see a blog where ppl actually reply – love it and will continue to follow here and on Facebook

          • MarkLloyd 5 years ago

            You’ve answered your own question;-) : Not hair for hair, & not collagen for collagen.

  4. Manuel 5 years ago

    Luv your videos but the sound quality sucks. Lost sound on last part of video about solubility good thing there is closed captions.

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