As creatine is generally neuro protective, and has benefits in some neuro-muscular diseases, mood, and so forth, as covered extensively on this site, so no surprises here for those who follow my work. More data needed, but very promising:
“Creatine monohydrate pilot in Alzheimer’s: Feasibility, brain creatine, and cognition”
Highlights
•Creatine monohydrate supplementation was feasible in patients with Alzheimer’s disease.
•Creatine monohydrate was associated with increased brain total creatine.
•Creatine monohydrate was associated with improvements in cognition.
•Efficacy of creatine monohydrate in Alzheimer’s disease should be studied further.
Abstract
BACKGROUND
Preclinical studies suggest that creatine monohydrate (CrM) improves cognition and Alzheimer’s disease (AD) biomarkers. However, there is currently no clinical evidence demonstrating the effects of CrM in patients with AD.
METHODS
In this single-arm pilot trial, we investigated the feasibility of 20 g/day CrM for 8 weeks in 20 patients with AD. We measured compliance throughout; serum creatine at baseline, 4 weeks, and 8 weeks; and brain total creatine (tCr) and cognition (National Institutes of Health [NIH] Toolbox, Mini-Mental State Examination [MMSE]) at baseline and 8 weeks.
RESULTS
Nineteen participants achieved the target of ≥80% compliance with the CrM intervention. Serum Cr was elevated at 4 and 8 weeks (p < .001) and brain tCr increased by 11% (p < .001). Cognition improved on global (p = .02) and fluid (p = .004) composites, List Sorting (p = .001), Oral Reading (p < .001), and Flanker (p = .05) tests.
DISCUSSION
Our data suggest that CrM supplementation is feasible in AD and provides preliminary evidence for future efficacy and mechanism studies.
Full Paper:
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.70101
Will Brink is the owner of the Brinkzone Blog. Will has over 30 years experience as a respected author, columnist and consultant, to the supplement, fitness, bodybuilding, and weight loss industry and has been extensively published. Will graduated from Harvard University with a concentration in the natural sciences, and is a consultant to major supplement, dairy, and pharmaceutical companies.
His often ground breaking articles can be found in publications such as Lets Live, Muscle Media 2000, MuscleMag International, The Life Extension Magazine, Muscle n Fitness, Inside Karate, Exercise For Men Only, Body International, Power, Oxygen, Penthouse, Women’s World and The Townsend Letter For Doctors.
He’s also been published in peer reviewed journals.
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